Divergent Transcription of the Nkx2-5 Locus Generates Two Enhancer RNAs with Opposing Functions
Irene Salamon, Simone Serio, Simona Bianco, Christina Pagiatakis, Silvia Crasto, Andrea M. Chiariello, Mattia Conte, Paola Cattaneo, Luca Fiorillo, Arianna Felicetta, Elisa Di Pasquale, Paolo Kunderfranco, Mario Nicodemi, Roberto Papait, Gianluigi Condorelli
Abstract
represses the activity of the enhancer through recruitment of the histone deacetylase sirtuin 1. Thus, we have identified an autoregulatory loop controlling expression of the master cardiac TF NKX2-5, in which one eRNA represses transcription.
Topics & Concepts
EnhancerEnhancer RNAsBiologyPromoterTranscription (linguistics)GeneGeneticsRegulation of gene expressionTranscription factorHistoneGene expressionCell biologyComputational biologyPhilosophyLinguisticsCancer-related molecular mechanisms researchRNA Research and SplicingRNA modifications and cancer