Genomic and transcriptomic alterations in m6A regulatory genes are associated with tumorigenesis and poor prognosis in head and neck squamous cell carcinoma.
Paramasivam Arumugam, Rinku George, Jayaseelan Vijayashree Priyadharsini
Abstract
had poor overall survival (OS) than those with low expression. Therefore, it is evident that IGF2BP family plays a key role in the oncogenesis of HNSCC and might serve as novel prognostic biomarkers and potential therapeutic targets in HNSCC.
Topics & Concepts
Head and neck squamous-cell carcinomaCarcinogenesisCancer researchBiologyGeneTranscriptomeDownregulation and upregulationGene expressionCancerHead and neck cancerGeneticsRNA modifications and cancerCancer-related gene regulationCancer-related molecular mechanisms research