N6-methylation of RNA-bound adenosine regulator HNRNPC promotes vascular endothelial dysfunction in type 2 diabetes mellitus by activating the PSEN1-mediated Notch pathway
Ying Cai, Tao Chen, Mingzhu Wang, Lihua Deng, Cui Li, Siqian Fu, Kangling Xie
Topics & Concepts
Notch signaling pathwayRNA methylationMedicineEndothelial dysfunctionMethylationDownregulation and upregulationVascular endothelial growth factor BUmbilical veinDNA methylationType 2 Diabetes MellitusEnosVascular endothelial growth factor CCell biologyVascular endothelial growth factor ACancer researchInternal medicineEndocrinologyDiabetes mellitusBiologyGene expressionSignal transductionVascular endothelial growth factorNitric oxide synthaseGeneNitric oxideBiochemistryMethyltransferaseVEGF receptorsIn vitroRNA modifications and cancerEpigenetics and DNA MethylationCancer-related gene regulation