Microfluidics-generated PLA nanoparticles: impact of purification method on macrophage interactions, anti-inflammatory effects, biodistribution, and protein corona formation
Jacob R. Shaw, Radha Vaidya, Fanny Xu, Shruti Dharmaraj, Ryan M. Pearson
Abstract
biodistribution studies suggested purification method-dependent alterations, which were correlated with protein corona profiles. This study underscores the potential of TFF, combined with microfluidics, as an efficient and high-yield purification method for NPs, and reveals the need for extensive confirmation of NP biological activity alongside physicochemical properties when developing NP therapeutics at-scale.
Topics & Concepts
BiodistributionMacrophageNanoparticleMicrofluidicsCorona (planetary geology)ChemistryNanotechnologyBiophysicsMaterials scienceBiologyBiochemistryIn vitroAstrobiologyVenusElectrospun Nanofibers in Biomedical ApplicationsNanoparticle-Based Drug DeliveryInfant Nutrition and Health