γ Peptide Nucleic Acid-Based miR-122 Inhibition Rescues Vascular Endothelial Dysfunction in Mice Fed a High-Fat Diet
Ravinder Reddy Gaddam, Karishma Dhuri, Young‐Rae Kim, Julia S. Jacobs, Vikas Kumar, Qiuxia Li, Kaikobad Irani, Raman Bahal, Ajit Vikram
Abstract
and demonstrates the suitability of γPNA technology in generating efficient and safer miR inhibitors.
Topics & Concepts
ChemistryEndothelial dysfunctionKidneyPeptide nucleic acidEndocrinologyInternal medicineToxicityPharmacologyNucleic acidBiochemistryMedicineMicroRNA in disease regulationRNA Interference and Gene DeliveryRNA Research and Splicing