Catalytic Enantioselective Azide–Alkyne Cycloaddition Chemistry Opens Up New Prospects for Chiral Triazole Syntheses
Chang-Qing Qin, Cheng Zhao, Guo‐Shu Chen, Yun‐Lin Liu
Abstract
Catalytic enantioselective azide–alkyne cycloaddition (E-AAC) is a highly efficient click technology for the construction of structurally diverse chiral triazoles, which have broad applications in fields of synthetic chemistry, medicinal chemistry, biological chemistry, and materials science. The past six years have seen impressive developments in copper-, nickel-, iridium-, and rhodium-catalyzed E-AAC reactions. This review provides a brief summary on this evolution according to the different strategies implemented.
Topics & Concepts
CycloadditionEnantioselective synthesisClick chemistryAlkyneRhodiumAzideCombinatorial chemistryCatalysisChemistryIridiumTriazoleOrganic chemistryClick Chemistry and ApplicationsHIV/AIDS drug development and treatmentChemical Synthesis and Analysis