Targeting the ABC transporter ABCB5 sensitizes glioblastoma to temozolomide-induced apoptosis through a cell-cycle checkpoint regulation mechanism
Catherine Lee, Pallavi Banerjee, Brian J. Wilson, Siyuan Wu, Qin Guo, Gretchen Berg, Svetlana A. Karpova, Ananda Mishra, John W. Lian, Johnathan Tran, Max Emmerich, Gëorge F. Murphy, Markus H. Frank, Natasha Y. Frank
Abstract
/M arrest and augments TMZ-mediated cell death. Our results identify ABCB5 as a GBM chemoresistance marker and point to the potential utility of targeting ABCB5 to improve current GBM therapies.
Topics & Concepts
TemozolomideCancer researchPTENCancer stem cellApoptosisCell cycleBiologyGliomaCancerMedicinePI3K/AKT/mTOR pathwayInternal medicineBiochemistryGlioma Diagnosis and TreatmentCancer Cells and MetastasisDrug Transport and Resistance Mechanisms