Total synthesis of landomycins Q and R and related core structures for exploration of the cytotoxicity and antibacterial properties
Yao-Hsuan Lai, Soumik Mondal, Hsin-Tzu Su, Sheng‐Cih Huang, Mine-Hsine Wu, I‐Wen Huang, Tsai-Ling Yang Lauderdale, Jen‐Shin Song, Kak‐Shan Shia, Kwok‐Kong Tony Mong
Abstract
Herein, we report the total synthesis of landomycins Q and R as well as the aglycone core, namely anhydrolandomycinone and a related core analogue.
Topics & Concepts
CytotoxicityCore (optical fiber)ChemistryAntibacterial activityCombinatorial chemistryStereochemistryMaterials scienceIn vitroBiochemistryGeologyBacteriaComposite materialPaleontologyBioactive Compounds and Antitumor AgentsSynthesis and Biological ActivityMicrobial Natural Products and Biosynthesis