SARS‐CoV‐2 spike protein positivity in pityriasis rosea‐like and urticaria‐like rashes of COVID‐19
Esperanza Welsh, Jesús Alberto Cárdenas‐de la Garza, Adrián Cuéllar‐Barboza, Rodolfo Franco‐Márquez, R.I. Arvizu‐Rivera
Abstract
The spike (S) protein of SARS-CoV-2 is responsible for receptor recognition and cell membrane fusion.1 Positive immunohistochemistry (IHC) for SARS-CoV/SARS-CoV-2 spike protein has been found in lungs, tracheal mucosa, renal tubular epithelial cells, and recently in chilblain-like and erythema multiforme-like lesions of patients with COVID-19.2 Herein, we report on two patients, one with a pityriasis rosea-like rash, and one with an urticarial rash with positive IHC for SARS-CoV/SARS-CoV-2 spike protein.
Topics & Concepts
Pityriasis roseaErythema multiformeRashImmunohistochemistrySpike ProteinMedicineDermatologyCoronavirusSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirologyCoronavirus disease 2019 (COVID-19)PathologyDiseaseInfectious disease (medical specialty)Dermatological and COVID-19 studiesParvovirus B19 Infection StudiesStreptococcal Infections and Treatments