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Design, synthesis and biological evaluation of a novel tubulin inhibitor SKLB0565 targeting the colchicine binding site

Xi Hu, Lu Li, Qiangsheng Zhang, Qianqian Wang, Zhanzhan Feng, Ying Xu, Yong Xia, Luoting Yu

2020Bioorganic Chemistry13 citationsDOIOpen Access PDF

Topics & Concepts

TubulinChemistryUmbilical veinApoptosisColchicineCell cycleMicrotubuleCell cycle checkpointMicrotubule polymerizationCell cultureCellCell growthBiochemistryCell biologyCancer researchIn vitroBiologyGeneticsSynthesis and biological activityCancer therapeutics and mechanismsBiochemical and Molecular Research
Design, synthesis and biological evaluation of a novel tubulin inhibitor SKLB0565 targeting the colchicine binding site | Litcius