A chitosan-coated PCL/nano-hydroxyapatite aerogel integrated with a nanofiber membrane for providing antibacterial activity and guiding bone regeneration
Xinyuan Deng, Chenghao Yu, Xiaopei Zhang, Xunmeng Tang, Qingxia Guo, Manfei Fu, Yuanfei Wang, Kuanjun Fang, Tong Wu
Abstract
osteogenesis analysis suggested that the PCL/n-HA aerogel could enhance the bone induction ability of bone mesenchymal stem cells, which was confirmed by the increased expression of the alkaline phosphatase activity. The loose structure facilitated the infiltration and migration of bone mesenchymal stem cells for better osteogenesis. In summary, such a composite scaffold exhibited excellent osteogenic and antibacterial properties as well as the barrier effect, thus holding promising potential for use as GBR materials.
Topics & Concepts
NanofiberChitosanRegeneration (biology)AerogelMembraneMaterials scienceNano-Antibacterial activityNanotechnologyChemical engineeringChemistryComposite materialBacteriaEngineeringBiochemistryGeneticsCell biologyBiologyElectrospun Nanofibers in Biomedical ApplicationsBone Tissue Engineering MaterialsAdvanced Photocatalysis Techniques