Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex
Laurent Fattet, Hae‐Yun Jung, Mike W. Matsumoto, Brandon E. Aubol, Aditya Kumar, Joseph A. Adams, Albert C. Chen, Robert L. Sah, Adam J. Engler, Elena B. Pasquale, Jing Yang
Topics & Concepts
MechanotransductionLYNExtracellular matrixBiologyMetastasisCell biologyEpithelial–mesenchymal transitionMechanosensitive channelsTwist transcription factorCancer researchIntegrinTumor microenvironmentSignal transductionCancerReceptorProto-oncogene tyrosine-protein kinase SrcGeneticsIon channelTumor cellsAxon Guidance and Neuronal SignalingCellular Mechanics and InteractionsCell Adhesion Molecules Research