Investigations on Anticancer and Antimalarial Activities of Indole-Sulfonamide Derivatives and <i>In Silico</i> Studies
Ratchanok Pingaew, Prasit Mandi, Veda Prachayasittikul, Anusit Thongnum, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul
Abstract
) for further synthesis and development as anticancer and antimalarial agents. Molecular docking was also performed to reveal possible modes of bindings and interactions between the studied compounds and target proteins. Taken together, insightful structure-activity relationship information obtained herein would be beneficial for future screening, design, and structural optimization of the related compounds.
Topics & Concepts
Quantitative structure–activity relationshipChemistryIndole testIn silicoStereochemistryAntimalarial AgentCancer cell linesSulfonamideDocking (animal)Combinatorial chemistryComputational chemistryCancer cellCancerBiochemistryBiologyPlasmodium falciparumGeneImmunologyMedicineGeneticsMalariaNursingComputational Drug Discovery MethodsSynthesis and biological activityChemical Synthesis and Analysis