Fusobacterium species are distinctly associated with patients with Lynch syndrome colorectal cancer
Felix Salim, Sayaka Mizutani, Satoshi Shiba, Hiroyuki Takamaru, Masayoshi Yamada, Takeshi Nakajima, Tatsuo Yachida, Tomoyoshi Soga, Yutaka Saitō, Shinji Fukuda, Shinichi Yachida, Takuji Yamada
Abstract
. Differential fecal metabolites and functional genes suggest heightened degradation of lysine and arginine in LS-CRC. A comparison between LS and non-LS subjects prior to adenoma formation revealed distinct fecal metabolites of LS subjects. These findings suggest that the gut microbiota plays a more responsive role in CRC tumorigenesis in patients with LS than those without LS.
Topics & Concepts
Colorectal cancerLynch syndromeFusobacteriumCancerMedicineBiologyInternal medicineGeneticsBacteroidesBacteriaDNA mismatch repairDiverticular Disease and ComplicationsGenetic factors in colorectal cancerColorectal Cancer Screening and Detection