Electrochemical cyclization of<i>N</i>-cyanamide alkenes with CF<sub>3</sub>SO<sub>2</sub>Na to access C,<i>N</i>-(bis)trifluoromethylated cyclic amidines and related compounds
Zhihua Yan, Wencheng Li, Yuheng Wu, Qi-Bo Yan, Zhonglin Wei, Wei‐Wei Liao
Abstract
An electrochemical trifluoromethylative cyclization of N -cyanamide alkenes and alkynes is presented, which afforded (bis)-C, N -trifluoromethylated cyclic amidines, azines and amides with selective multiple bond formations in a controllable manner.
Topics & Concepts
ChemistryCyanamideElectrochemistryMedicinal chemistryCyclic voltammetryOrganic chemistryElectrodePhysical chemistryFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsRadical Photochemical Reactions