Structure of <i>S. pombe</i> telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins
Ritwika Basu, Catherine D. Eichhorn, Ryan R. Cheng, Robert D. Peterson, Juli Feigon
Abstract
Pof8 RRM2. Sequence and structure comparison of Pof8 RRM2 to p65 and human Larp7 xRRMs reveals conserved features for RNA binding with the main variability in the length of the non-canonical helix α3. This study shows that Pof8 has conserved xRRM features, providing insight into TER recognition and the defining characteristics of the xRRM.
Topics & Concepts
BiologySchizosaccharomyces pombeRNA recognition motifRNARibonucleoproteinRNA-binding proteinSchizosaccharomycesGeneticsSignal recognition particle RNATelomeraseConserved sequenceCell biologySaccharomyces cerevisiaePeptide sequenceYeastGeneDNA Repair MechanismsRNA and protein synthesis mechanismsEnzyme Structure and Function