Severe Mpox Infections in People With Uncontrolled Human Immunodeficiency Virus
Anusha Govind, Susana Lazarte, Ellen Kitchell, Jeremy Chow, Carolee Estelle, Emma Fixsen, Caitlin Helm, Mamta K. Jain, Roma Mehta, Trish M. Perl, Jaini Sutaria, Cristina Thomas, Arturo R. Domínguez, Netanya S. Utay
Abstract
In the current mpox outbreak, infections are usually self-limited. We describe 3 patients with uncontrolled HIV and mpox infections lasting months, causing debilitating lesions, complications, and death, despite initiating anti-mpox and antiretroviral therapy. Delayed treatment of mpox with antiviral agents may contribute to poor outcomes in severely immunocompromised patients.
Topics & Concepts
MedicineHuman immunodeficiency virus (HIV)VirologyIntensive care medicineSidaViral diseaseImmunologyPoxvirus research and outbreaksBacillus and Francisella bacterial researchHerpesvirus Infections and Treatments