Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach
Kailey A. Wyman, Adel S. Girgis, Pragnakiran S. Surapaneni, Jade M. Moore, Noura M. Abo Shama, Sara H. Mahmoud, Ahmed Mostafa, Reham F. Barghash, Zou Juan, Radha D. Dobaria, Ahmad J. Almalki, Tarek S. Ibrahim, Siva S. Panda
Abstract
We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among all the synthesized conjugates, compound 9f showed potential against SARS-CoV-2 and low cytotoxicity. The conjugates’ selectivity indexes (SIs) were determined to correlate the antiviral properties and cytotoxicity. The observed biological data were further validated using computational studies.