A novel vaccinia virus enhances anti-tumor efficacy and promotes a long-term anti-tumor response in a murine model of colorectal cancer
Na Wang, Jiwei Wang, Zhe Zhang, Hua Cao, Wenli Yan, Yongchao Chu, Louisa S. Chard, Yaohe Wang
Abstract
T cells. Treatment resulted in development of long-term immunity against CMT93 tumor cells, as evidenced by prevention of disease recurrence. These results demonstrate that VVLΔTKΔN1L-mIL-21 is a promising therapeutic agent for treatment of CRC.
Topics & Concepts
VacciniaColorectal cancerVirologyVirusTerm (time)CancerCancer researchBiologyImmunologyMedicineInternal medicineGeneticsGenePhysicsRecombinant DNAQuantum mechanicsVirus-based gene therapy researchAnimal Virus Infections StudiesViral gastroenteritis research and epidemiology