Electrochemical oxidation-induced benzylic C(sp<sup>3</sup>)–H functionalization towards the atom-economic synthesis of oxazole heterocycles
Na Yang, Anni Li, Hui Gao, Li–Mei Liao, Yuping Yang, Pei-Long Wang, Hongji Li
Abstract
A unique electrochemical four-component reaction of terminal alkynes, (thio)xanthenes, nitriles, and water has been established in the absence of any catalyst or external oxidant.
Topics & Concepts
OxazoleSurface modificationElectrochemistryChemistryAtom (system on chip)Combinatorial chemistryMedicinal chemistryStereochemistryElectrodeEmbedded systemPhysical chemistryComputer scienceCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesOxidative Organic Chemistry Reactions