Nose-to-brain delivery of phenytoin and its hydrophilic prodrug fosphenytoin combined in a microemulsion - formulation development and in vivo pharmacokinetics.
Patrícia C. Pires, Ana C. Fazendeiro, Márcio Rodrigues, Gilberto Alves, Adriana O. Santos
Topics & Concepts
ProdrugBioavailabilityPharmacokineticsPharmacologyChemistryMicroemulsionPhenytoinIn vivoNasal administrationDrug deliveryDrugMedicineOrganic chemistryEpilepsyBiochemistryBiologyPsychiatryBiotechnologyPulmonary surfactantPharmacological Effects and Toxicity StudiesEpilepsy research and treatmentDrug Transport and Resistance Mechanisms