Bidirectional airflow in lung airway-on-a-chip with matrix-derived membrane elicits epithelial glycocalyx formation
Siwan Park, Jeremy D. Newton, Tesnime Hidjir, Edmond W. K. Young
Abstract
models, as bidirectional airflow showed more representative mucociliary differentiation compared to continuous unidirectional airflow. Thus, the lung airway-on-a-chip platform demonstrated in this study holds great potential as a lung epithelial barrier model for studying the mechanisms of various respiratory diseases and for testing the efficacy of therapeutic candidates in the presence of bidirectional airflow and the glycocalyx.
Topics & Concepts
GlycocalyxAirflowCell biologyAirwayLungMucusOrgan-on-a-chipExtracellular matrixChemistryImmunologyBiologyBiophysicsMaterials scienceNanotechnologyMicrofluidicsMedicineInternal medicineEngineeringAnesthesiaMechanical engineeringEcology3D Printing in Biomedical ResearchInhalation and Respiratory Drug DeliveryBlood transfusion and management