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Discovery of a potent and selective PARP1 degrader promoting cell cycle arrest via intercepting CDC25C-CDK1 axis for treating triple-negative breast cancer

Yiquan Wu, Mingfei Wu, Xiaoli Zheng, Hengyuan Yu, Xinfei Mao, Yuyuan Jin, Yanhong Wang, Ao Pang, Jingyu Zhang, Shenxin Zeng, Tengfei Xu, Yong Chen, Bo Zhang, Nengming Lin, Haibin Dai, Yuwei Wang, Xiaojun Yao, Xiaowu Dong, Wenhai Huang, Jinxin Che

2023Bioorganic Chemistry21 citationsDOI

Topics & Concepts

Triple-negative breast cancerChemistryCancer researchCyclin-dependent kinase 1PARP1Breast cancerCell cycle checkpointDNA damageCell cycleCancerPharmacologyCellBiochemistryPoly ADP ribose polymeraseBiologyMedicineInternal medicineEnzymeDNAPolymerasePARP inhibition in cancer therapyProtein Degradation and InhibitorsIntegrated Circuits and Semiconductor Failure Analysis
Discovery of a potent and selective PARP1 degrader promoting cell cycle arrest via intercepting CDC25C-CDK1 axis for treating triple-negative breast cancer | Litcius