Sult2b1 deficiency exacerbates ischemic stroke by promoting pro-inflammatory macrophage polarization in mice
Yan Wang, Haojie Jin, Yafang Wang, Yang Yao, Cuixia Yang, Jihong Meng, Xiaomu Tan, Yu Nie, Lixiang Xue, Baohui Xu, Heng Zhao, Feng Wang
Abstract
promoted the polarization of macrophages into pro-inflammatory status. This trend could be attenuated by adding cholesterol sulfate, which promotes the polarization of macrophages into anti-inflammatory status by metabolic regulation. In this study, we established an inflammation-metabolism axis during the macrophage polarization after ischemic stroke.
Topics & Concepts
NeuroinflammationImmune systemMonocyteInternal medicineEndocrinologyMedicineCholesterolMacrophage polarizationReactive oxygen speciesChemistryNicotinamide adenine dinucleotide phosphateInflammationImmunologyMacrophageBiochemistryOxidase testIn vitroEnzymeNeuroinflammation and Neurodegeneration MechanismsImmune cells in cancerCholesterol and Lipid Metabolism