A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways
Patrícia Danielle Oliveira de Almeida, Gleyce dos Santos Barbosa Jobim, Caio César dos Santos Ferreira, Lucas Rocha Bernardes, Rosane B. Dias, Caroline Brandi Schlaepfer Sales, Ludmila de Faro Valverde, Clarissa Araújo Gurgel Rocha, Milena Botelho Pereira Soares, Daniel P. Bezerra, Fernando de Carvalho da Silva, Mariana Cardoso, Vı́tor F. Ferreira, Larissa Froede Brito, Lirlândia P. Sousa, Marne Carvalho de Vasconcellos, Émerson Silva Lima
Topics & Concepts
ApoptosisKinasep38 mitogen-activated protein kinasesCell biologyChemistryBiologySignal transductionCytotoxic T cellMolecular biologyRHOAProtein kinase ABiochemistryIn vitroBioactive Compounds and Antitumor AgentsCancer therapeutics and mechanismsSynthesis and biological activity