Glutathione-triggered nanoplatform for chemodynamic/metal-ion therapy
Min Liu, Hongshuai Wu, Senlin Wang, Jinzhong Hu, Bai‐Wang Sun
Abstract
to the highly toxic ˙OH by a Fenton-like reaction. Meanwhile, Ag NPs were oxidized to toxic Ag ions in the tumor environment. As expect, the effect of CDT combined with metal-ion therapy exhibited an excellent inhibition of tumor cells growth. Therefore, this nanoplatform may provide a promising strategy for on-demand site-specific cancer combination treatment.
Topics & Concepts
GlutathioneMetal ions in aqueous solutionMetalIonHydroxyl radicalChemistryCombinatorial chemistryBiophysicsBiochemistryRadicalBiologyOrganic chemistryEnzymeNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryAdvanced Nanomaterials in Catalysis