GPR30 alleviated subarachnoid hemorrhage-induced blood-brain barrier dysfunction by activating the PI3K/Akt and Nrf2/HO-1 pathways
Jun Peng, Jun He, Xiqi Hu, Ying Xia
Abstract
The PI3K/Akt and Nrf2/HO-1 pathways might be potential mechanisms by which GPR30 protected the integrity of the BBB in SAH models. Therefore, treatment of SAH with GPR30 activator might be a promising therapeutic strategy.
Topics & Concepts
PI3K/AKT/mTOR pathwayProtein kinase BMedicineGPERSubarachnoid hemorrhageBlood–brain barrierInternal medicineSignal transductionBiologyCell biologyEstrogen receptorCentral nervous systemCancerBreast cancerIntracerebral and Subarachnoid Hemorrhage ResearchIntracranial Aneurysms: Treatment and ComplicationsNeurosurgical Procedures and Complications