Membrane surface recognition by the ASAP1 PH domain and consequences for interactions with the small GTPase Arf1
Olivier Soubias, Shashank Pant, Frank Heinrich, Yue Zhang, Neeladri Sekhar Roy, Jess Li, Xiaoying Jian, Marielle E. Yohe, Paul A. Randazzo, Mathias Lösche, Emad Tajkhorshid, R. Andrew Byrd
Abstract
The ASAP1 PH domain binds to PIP 2 membranes, experiences conformational shifts, and recognizes Arf1 to initiate GTPase activity.
Topics & Concepts
GTPaseSmall GTPaseMembraneAmphiphileDomain (mathematical analysis)BiophysicsCell biologyConformational changeChemistryCrystallographyBiologyBiochemistrySignal transductionPolymerMathematical analysisOrganic chemistryCopolymerMathematicsCellular transport and secretionErythrocyte Function and PathophysiologyProtein Kinase Regulation and GTPase Signaling