Tumor-Derived Membrane Vesicles: A Promising Tool for Personalized Immunotherapy
Jiabin Xu, Wen‐Qiang Cao, Penglai Wang, Hong Liu
Abstract
Tumor-derived membrane vesicles (TDMVs) are non-invasive, chemotactic, easily obtained characteristics and contain various tumor-borne substances, such as nucleic acid and proteins. The unique properties of tumor cells and membranes make them widely used in drug loading, membrane fusion and vaccines. In particular, personalized vectors prepared using the editable properties of cells can help in the design of personalized vaccines. This review focuses on recent research on TDMV technology and its application in personalized immunotherapy. We elucidate the strengths and challenges of TDMVs to promote their application from theory to clinical practice.
Topics & Concepts
ImmunotherapyVesiclePersonalized medicineNucleic acidMembraneTumor cellsComputational biologyChemistryNanotechnologyCancer researchMedicineBioinformaticsBiologyMaterials scienceImmune systemImmunologyBiochemistryExtracellular vesicles in diseaseRNA Interference and Gene DeliveryNanoplatforms for cancer theranostics