<i>Akkermansia muciniphila</i> ameliorates depressive disorders in a murine alcohol-LPS (mALPS) model
Dingming Guo, Chaiwoo Park, Yun Li, Bei Li, Qianqian Yang, Yun Deng, Na Gao, Rong Li, Xiangfeng Wang, Liwen Yi, Zhi Liu
Abstract
(AKK), one of the next-generation probiotics, has been widely used for the restoration of the intestinal barrier and reduction of inflammation. Here, we found that AKK significantly ameliorated alcohol-related depressive behaviors in a mALPS model, through enhancing the intestinal barrier and maintaining the homeostasis of the gut microbiota. Furthermore, AKK reduced serum LPS, ameliorated neuroinflammation (TNF-α and IL-1β), normalized the expression of depression-related genes and increased the 5-HT levels in the hippocampus. Our study suggests that AKK supplements will be a promising therapeutic regime for alcohol-associated depression in the future.