Dynamic adoption of anergy by antigen-exhausted CD4+ T cells
Anne Trefzer, Pallavi Kadam, Shu-Hung Wang, Stefanie Pennavaria, Benedikt Lober, Batuhan Akçabozan, Jan Kranich, Thomas Brocker, Naoko Nakano, Martin Irmler, Johannes Beckers, Tobias Straub, Reinhard Obst
Abstract
T cells to different levels of persisting antigen and contribute to a better understanding of chronic disease.
Topics & Concepts
AntigenClonal anergyImmunologyImmune systemT-cell receptorBiologyCD28Cytotoxic T cellCell biologyEffectormTORC1CalcineurinDownregulation and upregulationAntigen presentationAntigen-presenting cellTranscriptomeT cellSignal transductionMedicineGene expressionTransplantationPI3K/AKT/mTOR pathwayGeneGeneticsInternal medicineIn vitroImmune Cell Function and InteractionT-cell and B-cell ImmunologyCAR-T cell therapy research