Recent Progress in the Understanding of the Effect of Sympathetic Nerves on Hair Follicle Growth
Jiarui Zhang, Ruosi Chen, Lihong Wen, Zhexiang Fan, Yilong Guo, Zhiqi Hu, Yong Miao
Abstract
Clinical observation and experimental studies have long suggested that the perifollicular nerves have nutritional and regulatory effects on the growth, development, and physiological cycle of hair follicles (HFs), even though the concrete mechanism remains obscure. Recently, with the progress of immunohistochemistry and molecular biology techniques, more innovation has been made in the study of the follicular sympathetic nerves and its nerve-effect factor norepinephrine affecting hair follicle stem cells. This review highlights the progress in the regulation of the sympathetic nervous system toward the growth of HFs.
Topics & Concepts
Hair follicleSympathetic nervous systemNerve growth factorNorepinephrineBiologyMechanism (biology)FollicleAutonomic nervous systemImmunohistochemistryFollicular phaseEndocrinologyInternal medicineNeuroscienceMedicineImmunologyReceptorDopamineEpistemologyBlood pressurePhilosophyHeart rateHair Growth and DisordersSkin and Cellular Biology ResearchWnt/β-catenin signaling in development and cancer