Gut‑liver axis in liver disease: From basic science to clinical treatment (Review)
Jianpeng Wang, Xinyi Wang, Enba Zhuo, Bangjie Chen, Shixin Chan
Abstract
Incidence of a number of liver diseases has increased. Gut microbiota serves a role in the pathogenesis of hepatitis, cirrhosis and liver cancer. Gut microbiota is considered 'a new virtual metabolic organ'. The interaction between the gut microbiota and liver is termed the gut‑liver axis. The gut‑liver axis provides a novel research direction for mechanism of liver disease development. The present review discusses the role of the gut‑liver axis and how this can be targeted by novel treatments for common liver diseases.
Topics & Concepts
DiseaseMolecular medicineCell cycleOncogeneLiver diseaseLiver cancerMedicineBiologyCancerPathologyInternal medicineLiver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease