PKD2 deficiency suppresses amino acid biosynthesis in ADPKD by impairing the PERK–TBL2–eIF2ɑ–ATF4 pathway
Xingquan Zhou, Hui Xiong, Yi Lu, Meijuan Geng, Yumei Lu, Lirong Zhang, Xu Zhu
Topics & Concepts
BiosynthesisATF4Amino acidBiochemistryChemistryBiologyEndocrinologyUnfolded protein responseEnzymeGeneGenetic and Kidney Cyst DiseasesEndoplasmic Reticulum Stress and DiseaseGenetics and Neurodevelopmental Disorders