Tumor cell–organized fibronectin maintenance of a dormant breast cancer population
Lauren E. Barney, Christopher L. Hall, Alyssa D. Schwartz, Akia N. Parks, Christopher Sparages, Sualyneth Galarza, Manu O. Platt, Arthur M. Mercurio, Shelly R. Peyton
Abstract
integrin adhesion, ROCK-generated tension, and TGFβ2 stimulation, and cancer cell outgrowth after dormancy required MMP-2-mediated fibronectin degradation. We propose this approach as a useful, in vitro method to study factors important in regulating dormancy, and we used it here to elucidate a role for fibronectin deposition and MMP activation.
Topics & Concepts
Breast cancerFibronectinCellPopulationBiologyCancerCancer researchMedicinePathologyGeneticsEnvironmental healthCell Adhesion Molecules ResearchCellular Mechanics and InteractionsAngiogenesis and VEGF in Cancer