Apoptosis signal-regulating kinase 1 (ASK1) inhibition reduces endothelial cytokine production without improving permeability after toll-like receptor 4 (TLR4) challenge
Michael R. Miller, Stephen R. Koch, Hyehun Choi, Fred S. Lamb, Ryan J. Stark
Topics & Concepts
ASK1p38 mitogen-activated protein kinasesTLR4Cell biologyCytokineProinflammatory cytokineBiologyMAPK/ERK pathwaySignal transductionKinaseCancer researchInflammationImmunologyProtein kinase AMitogen-activated protein kinase kinaseS100 Proteins and AnnexinsRedox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative Mechanisms