The anti-Trop-2 antibody-drug conjugate Sacituzumab Govitecan—effectiveness, pitfalls and promises

Abstract

On April 22, 2020, the Food and Drug Administration (FDA) granted accelerated approval to sacituzumab govitecan-hziy (TRODELVY, Immunomedics, Inc.) (SG) for patients with metastatic triple-negative breast cancer (TNBC), who had received at least two prior therapies for metastatic disease (1). SG is an antibody-drug conjugate (ADC) of a humanized anti-Trop-2 monoclonal antibody (mAb), HuRS7, linked to 8 molecules of SN-38-the active metabolite of irinotecan and a potent inhibitor of topoisomerase 1 (2). Notably, until SG no topoisomerase I inhibitors had been used in metastatic TNBC, and SG effectively constitutes a new cytotoxic drug, for treating a disease that still heavily depended on chemotherapy.

Topics & Concepts