Obesity protects against sepsis-induced and norepinephrine-induced white adipose tissue browning
Cheryl Li, Xenia Davis, Patrick Lahni, Joanna Stuck, Lauren Williamson, Jennifer Kaplan
Abstract
White adipose tissue browning is detrimental in patients with burn injury and cancer. WAT browning occurs in nonobese mice and can be induced by β receptor norepinephrine infusion, but obese mice are resistant to sepsis-induced and norepinephrine-induced WAT browning. We propose that the lack of WAT browning and unchanged inflammatory cytokine response may contribute to the protection of obese mice from sepsis.
Topics & Concepts
White adipose tissueBrowningAdipose tissueNorepinephrineSepsisObesityEndocrinologyInternal medicineMedicineChemistryFood scienceDopamineAdipose Tissue and MetabolismThermoregulation and physiological responsesAdipokines, Inflammation, and Metabolic Diseases