Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brain
Jacob G. Smith, Tomoki Sato, Kouhei Shimaji, Kevin B. Koronowski, Paul Petrus, Marlene Cervantes, Kenichiro Kinouchi, Dominik Lutter, Kenneth A. Dyar, Paolo Sassone‐Corsi
Abstract
The gut microbiome influences cognition and behavior in mammals, yet its metabolic impact on the brain is only starting to be defined. Using metabolite profiling of antibiotics-treated mice, we reveal the microbiome as a key input controlling circadian metabolic cycles in the brain. Intra and inter-region analyses characterise the influence of the microbiome on the suprachiasmatic nucleus, containing the central clockwork, as well as the hippocampus and cortex, regions involved in learning and behavior.
Topics & Concepts
MicrobiomeGut microbiomeCircadian rhythmBiologyNeuroscienceSuprachiasmatic nucleusHippocampusPhysiologyBioinformaticsTryptophan and brain disordersNeuroendocrine regulation and behaviorDiet and metabolism studies