Litcius/Paper detail

XAF1 as a modifier of p53 function and cancer susceptibility

Emília M. Pinto, Bonald C. Figueiredo, Wenan Chen, Henrique C.R. Galvão, Maria Nirvana Formiga, Maria Candida Barisson Villares Fragoso, Patrícia Ashton‐Prolla, Enilze M.S.F. Ribeiro, Gabriela Trindade Felix, Tatiana EI-Jaick B. Costa, Sharon A. Savage, Meredith Yeager, Edenir Inêz Palmero, Sáhlua Miguel Volc, Hector Salvador, José Luis Fuster‐Soler, Cinzia Lavarino, Guillermo Chantada, Dominique Vaur, Vicente Odone Filho, Laurence Brugières, Tobias Else, Elena M. Stoffel, Kara N. Maxwell, Maria Isabel Achatz, Luiz Paulo Kowalski, Kelvin C. de Andrade, Alberto S. Pappo, Éric Letouzé, Ana Cláudia Latronico, Berenice B. Mendonça, Madson Q. Almeida, Vania Balderrama-Brondani, Camila Matzenbacher Bittar, Emerson Wander Silva Soares, Carolina Mathias, Cíntia Regina Niederauer Ramos, Moara Machado, Weiyin Zhou, Kristine Jones, Aurélie Vogt, Payal P. Klincha, Karina Miranda Santiago, Heloísa Komechen, Mariana M. Paraizo, Ivy Z.S. Parise, Kayla V. Hamilton, Jinling Wang, Evadnie Rampersaud, Michael R. Clay, Andrew J. Murphy, Enzo Lalli, Kim E. Nichols, Raul C. Ribeiro, Carlos Rodríguez‐Galindo, Márta Korbonits, Jinghui Zhang, Mark Thomas, Jon P. Connelly, Shondra M. Pruett‐Miller, Yoan Diekmann, Geoffrey Neale, Gang Wu, Gerard P. Zambetti

2020Science Advances56 citationsDOIOpen Access PDF

Abstract

The XAF1 -E134* variant increases the cancer risk for carriers of the TP53 -R337H allele.

Topics & Concepts

HaplotypeAlleleGeneticsTransactivationCancerSuppressorBiologyPhenotypeMutantGeneMutationTumor suppressor geneGenomeCancer researchCarcinogenesisTranscription factorCancer-related Molecular PathwaysCancer Genomics and DiagnosticsUbiquitin and proteasome pathways