Impact of the central atom and halido ligand on the structure, antiproliferative activity and selectivity of half-sandwich Ru(<scp>ii</scp>) and Ir(<scp>iii</scp>) complexes with a 1,3,4-thiadiazole-based ligand
Radka Křikavová, Michaela Romanovová, Zuzana Jendželovská, Martin Majerník, Lukáš Masaryk, Pavel Zoufalý, David Milde, Ján Moncóľ, Radovan Herchel, Rastislav Jendželovský, Ivan Němec
Abstract
(CCD-18Co)), including the cisplatin-resistant cancer cell line. Based on these findings, it is possible to emphasize that mainly complex 4 could represent a further step in the development of selective and highly effective anticancer agents, particularly against resistant tumour types.
Topics & Concepts
SelectivityLigand (biochemistry)ChemistryAtom (system on chip)StereochemistryCatalysisReceptorBiochemistryComputer scienceEmbedded systemMetal complexes synthesis and propertiesClick Chemistry and Applications