Applying Lipidomics to Non-Alcoholic Fatty Liver Disease: A Clinical Perspective
Jian Huang, Giordano Sigon, Benjamin H. Mullish, Dan Wang, Rohini Sharma, Pinelopi Manousou, Roberta Forlano
Abstract
The prevalence of Non-alcoholic fatty liver disease (NAFLD) and associated complications, such as hepatocellular carcinoma (HCC), is growing worldwide, due to the epidemics of metabolic risk factors, such as obesity and type II diabetes. Among other factors, an aberrant lipid metabolism represents a crucial step in the pathogenesis of NAFLD and the development of HCC in this population. In this review, we summarize the evidence supporting the application of translational lipidomics in NAFLD patients and NAFLD associated HCC in clinical practice.
Topics & Concepts
LipidomicsFatty liverHepatocellular carcinomaMedicineDiseaseMetabolic syndromePopulationPathogenesisType 2 diabetesObesityDiabetes mellitusInternal medicineBioinformaticsLipid metabolismBiologyEndocrinologyEnvironmental healthLiver Disease Diagnosis and TreatmentLipid metabolism and biosynthesisEndoplasmic Reticulum Stress and Disease