Historical perspective on ruthenium-catalyzed hydrogen transfer and survey of enantioselective hydrogen auto-transfer processes for the conversion of lower alcohols to higher alcohols
Eliezer Ortiz, Jonathan Z. Shezaf, Weijia Shen, Michael J. Krische
Abstract
Ruthenium-catalyzed hydrogen auto-transfer reactions for the direct enantioselective conversion of lower alcohols to higher alcohols are surveyed. These processes enable completely atom-efficient carbonyl addition from alcohol proelectrophiles in the absence of premetalated reagents or metallic reductants. Applications in target-oriented synthesis are highlighted, and a brief historical perspective on ruthenium-catalyzed hydrogen transfer processes is given.
Topics & Concepts
RutheniumEnantioselective synthesisCatalysisChemistryHydrogen atomHydrogenTransfer hydrogenationAlcoholReagentCombinatorial chemistryAlcohol oxidationOrganic chemistryAlkylAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisSurface Chemistry and Catalysis