Practical synthesis of quinolone drugs <i>via</i> a novel TsCl-mediated domino reaction sequence
Jie Lei, Yong Ding, Haoyi Zhou, Xinyan Gao, Yi-Hua Cao, Dianyong Tang, Hongyu Li, Zhigang Xu, Zhong‐Zhu Chen
Abstract
A novel TsCl-mediated domino sequence to expeditiously access quinolone-based antibiotics, starting from commercially available chromone-3-carboxaldehydes and amines, was developed under environmentally benign conditions.
Topics & Concepts
Sequence (biology)DominoQuinoloneChemistryCombinatorial chemistryStereochemistryOrganic chemistryBiochemistryAntibioticsCatalysisSynthesis and Biological EvaluationCarbohydrate Chemistry and SynthesisSynthesis of Organic Compounds