Identification of novel glucocerebrosidase chaperone for potential treatment of Parkinson's disease: An approach using in silico virtual screening, molecular docking and molecular dynamics, and in vitro studies
Pratigya Tripathi, Ankit Ganeshpurkar, Sushil Kumar Singh, Sairam Krishnamurthy
Topics & Concepts
In silicoGlucocerebrosidaseCircular dichroismVirtual screeningChemistryChaperone (clinical)Molecular dynamicsDocking (animal)Chemical chaperoneBiophysicsBiochemistryEnzymeBiologyDrug discoveryMutantGeneComputational chemistryMedicineNursingPathologyLysosomal Storage Disorders ResearchEndoplasmic Reticulum Stress and DiseaseAlzheimer's disease research and treatments