Bioactive Peptides from Lupin (<i>Lupinus angustifolius</i>) Prevent the Early Stages of Atherosclerosis in Western Diet-Fed ApoE<sup>–/–</sup> Mice
Guillermo Santos‐Sánchez, Ivan Cruz‐Chamorro, Ana Isabel Álvarez‐Ríos, Nuria Álvarez‐Sánchez, Beatriz Rodríguez-Ortiz, Ana Isabel Álvarez‐López, María‐Soledad Fernández‐Pachón, Justo Pedroche, Francisco Millán, María C. Millán-Linares, Patricia Judith Lardone, Ignacio Bejarano, Antonio Carrillo‐Vico
Abstract
LPH effects on atherosclerosis risk factors in a mouse model of atherosclerosis. After 15 min of Alcalase hydrolysis, peptides smaller than 8 kDa were obtained, and 259 peptides out of 278 peptides found showed biological activities related to atherosclerosis risk factors. Furthermore, LPH administration for 12 weeks reduced the plasma lipids, as well as the cardiovascular and atherogenic risk indexes. LPH also increased the total antioxidant capacity, decreased endothelial permeability, inflammatory response, and atherogenic markers. Therefore, this study describes for the first time that LPH prevents the early stages of atherosclerosis.