Palbociclib and Michael-acceptor hybrid compounds as CDK4/6 covalent inhibitors: Improved potency, broad anticancer spectrum and overcoming drug resistance
Lei Fang, Mengqi Chu, Changhang Yan, Yilin Liu, Zimeng Zhao
Topics & Concepts
ChemistryPalbociclibStereochemistryCovalent bondCell cycleIC50BiochemistryApoptosisIn vitroCancerOrganic chemistryBiologyBreast cancerMetastatic breast cancerGeneticsAdvanced Breast Cancer TherapiesCancer-related Molecular PathwaysChronic Lymphocytic Leukemia Research