Two-Component Response Regulator OmpR Regulates Mucoviscosity through Energy Metabolism in Klebsiella pneumoniae
Lijun Wang, Xueting Huang, Qian Jin, Jie Tang, Hua Zhang, Jing-Ren Zhang, Hui Wu
Abstract
mutant phenotype. Our findings provide new insights into the regulation of K. pneumoniae hypermucoviscosity by a two-component signal transduction system, highlighting the previously unknown role of OmpR in regulating bacterial energy status and its influence on hypermucoviscosity.
Topics & Concepts
Klebsiella pneumoniaeVirulenceBiologyRegulatorResponse regulatorMicrobiologyBacterial proteinEnergy metabolismGeneGeneticsEscherichia coliEndocrinologyAntibiotic Resistance in BacteriaPneumonia and Respiratory InfectionsCancer therapeutics and mechanisms