Electroselective C(sp<sup>3</sup>)–H deuteration of isoindolinones
Qiansong Gao, Lianyou Zheng, Shulin Ning, Lingling Shi, Cheng Wu, Mian Liu, Jinbao Xiang
Abstract
An efficient paired electrochemical method for selective deuteration of isoindolinones was realized via H/D exchange. Its utility has been well exemplified in the late-stage modification of bioactive molecules and their further transformation.
Topics & Concepts
ChemistryElectrochemistryMoleculeCombinatorial chemistryTransformation (genetics)ElectrodeOrganic chemistryPhysical chemistryBiochemistryGeneChemical Reactions and IsotopesCoordination Chemistry and OrganometallicsAsymmetric Hydrogenation and Catalysis