Co-localization of carbapenem (<i>bla</i>OXA-162) and colistin (<i>mcr-1</i>) resistance genes on a transferable IncHI2 plasmid in <i>Escherichia coli</i> of chicken origin
Valeria Bortolaia, Troels Ronco, Luminiţa Maria Romaşcu, I. Nicorescu, Nicoleta Manuela Miliţă, Angela M Vaduva, Pimlapas Leekitcharoenphon, Jette Sejer Kjeldgaard, Inge M. Hansen, Christina Aaby Svendsen, Hanne Mordhorst, Beatriz Guerra, Pierre‐Alexandre Belœil, Maria Hoffmann, René S. Hendriksen
Abstract
Carbapenems are critically important antimicrobials for the treatment of clinical infections caused by MDR Enterobacteriaceae, with colistin reserved for those cases in which even carbapenems are ineffective. Therefore, co-localization of carbapenem and colistin resistance genes on the same plasmid is worrisome and, to date, has been described only in China in an Escherichia coli from a diseased chicken (blaNDM-4 and mcr-1 on an IncHI2/ST3 plasmid)1 and in an E. coli from a diseased pet cat (blaNDM-5 and mcr-1 on an IncX3-X4 hybrid plasmid).2 Here, we report a novel case of co-localization of blaOXA-162 carbapenemase and mcr-1 on a transferable IncHI2 plasmid in E. coli from a healthy broiler chicken in Europe.